DHEA supplementation: The claims in perspective CURRENT DRUG THERAPY
نویسنده
چکیده
EWA OLECH, MD Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation; Clinical Assistant Professor, University of Oklahoma Health Sciences Center, Oklahoma City JOAN T. MERRILL, MD* Head, Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, and Professor of Medicine, Oklahoma Health Sciences Center, Oklahoma City; Medical Director, Lupus Foundation of America
منابع مشابه
Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization
Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in the circulation and has potent multifunctional activity. Epidemiological evidence suggests that levels of serum DHEA decrease with advancing age, and this has been associated with onset or progression of various age-related ailments, including cognitive decline and dementia, cardiovascular disease, and obesity. Consequently, ...
متن کاملDHEA as a miracle drug in the treatment of poor responders; hype or hope?
Dehydroepiandrosterone (DHEA) is being presented as a miracle-drug for the treatment of women responding poorly to gonadotrophin stimulation, while the debate on its actual effectiveness is still ongoing. We would like to present how insufficient the current evidence of acceptable quality is to warrant a conclusion that DHEA supplementation is an effective treatment for women with diminished ov...
متن کاملDHEA therapy for women: effect on sexual function and wellbeing.
DHEA is increasingly available commercially as a supplement aimed at improving libido and wellbeing in postmenopausal women. However there is scant evidence to support the use of DHEA for this purpose, and safety data for DHEA therapy are lacking. Dehydroepiandrosterone (DHEA) and its sulphate DHEAS are the most abundant circulating sex steroid hormones in women, providing a large precursor res...
متن کاملLong-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids.
OBJECTIVE To evaluate the effects of a low-dose DHEA supplementation on hormonal parameters in early and late postmenopausal women. DESIGN Prospective case study. SETTING Postmenopausal women in a clinical research environment. PATIENT(S) Twenty postmenopausal women were divided in two groups according to age (50-55 and 60-65 years). INTERVENTION(S) All patients underwent hormonal evalu...
متن کاملP02.62. DHEA augmentation strategy for treatment of fatigue and depression: a case presentation
Purpose Dehydroepiandrosterone (DHEA) and its sulfated derivative DHEA-S are endogenous hormones secreted by the adrenal cortex in response to ACTH and stress. Levels of DHEA and DHEA-S are decreased with advancing age and depression. Trials of DHEA for mid-life depression have shown promising yet inconclusive results, due in part to small sample sizes and lack of placebo comparators. An additi...
متن کامل